A leave behind from Vincent Hembrick after the EntityRisk AE interview with Ali Ruderian, covering category point of view, ICP read, mock outbound sequence, first 90 day plan, and year one commitments.
Prepared for the team at EntityRisk
By Vincent Hembrick
Why I built this
Ali, thank you for the conversation yesterday. I wanted to leave you with a clearer picture of how I think about the AE role at EntityRisk.
I sell into the exact buying committee EntityRisk is selling into. In my current role as a BDR at Certara, I prospect and multi thread VP, Director, and C level stakeholders across pharma and biotech. The language, the stakeholders, the buying cycles, and the signals that drive outbound success in this market are already my daily work.
What I bring that many AE candidates do not: a proven outbound motion built from zero, top ranked attainment inside a complex regulated category, and an engineering background that lets me hold my own in a room full of PhDs without needing a data scientist to translate for me.
Three forces pushing biopharma HEOR teams toward software
Faster than at any point in the last decade.
The Inflation Reduction Act is in its enforcement phase, not its debate phase
CMS released detailed explanations of the first round of negotiated prices in early 2025. That transparency puts every future negotiation candidate on notice that they need defensible, auditable, adaptable models to protect price. A one off consulting engagement does not produce a living model that can be updated when CMS asks a new question in 2027.
Most Favored Nation pricing pressure has shifted the conversation from defensive to preemptive
Boards are asking their CFOs and CCOs to model MFN scenarios today, not when a proposal drops. PROVEN's ability to simulate multi geography price distributions and contracting scenarios lands directly on that boardroom question.
EU Joint Clinical Assessment is live for oncology and ATMPs
Any biopharma launching globally now needs a single value model that can be adapted across member state requirements without model drift. This is a software problem, not a consulting problem. The consultancies know it, which is why they are racing to bolt tools onto their services offerings. EntityRisk is already there.
Where the growth wedge sits
EntityRisk's website states that ten of the top twenty biopharma companies are customers, which establishes enterprise credibility. The more interesting commercial story is the growth wedge.
Enterprise anchor (top 20 pharma)
High ACV, long cycles, multi year, multi product expansion. Commercial lead is often an HEOR or Value Lead with a clear CFO sponsor.
Mid cap biotech approaching NDA or BLA
Fastest velocity segment. They have Phase 3 readouts, an ICER or HTA clock, and often no internal HEOR team large enough to build from scratch. The Manish Singh hire announcement explicitly called out this segment as a growth priority.
Late stage diagnostic and device with US market entry
Confirmed by the Cleo Diagnostics partnership in August 2025. Smaller ACV but a durable adjacent segment with clear economic buyer alignment.
Investor due diligence
PE and late stage healthcare investors using PROVEN for commercial diligence on buyout candidates. Different motion, different stakeholder, but the same underlying software.
The mid cap biotech segment is where a full cycle AE with outbound muscle can compound fastest. Enterprise deals move on relationships and brand that take time to build. Mid cap biotech moves on triggers: Phase 3 readouts, pre NDA meetings, PDUFA dates, recent capital raises for launch prep, VP of HEOR hires, VP of Market Access hires. Those signals are exactly what I built my Certara outbound playbook around.
How I would actually work a named account
Representative of the mid cap biotech segment I believe EntityRisk should be prioritizing.
Archetype: late stage cardiometabolic biotech approaching first NDA
Five touch cadence into the archetype
Email, LinkedIn, phone, value email, breakup. Tuned to a VP HEOR persona at a Phase 3 cardiometabolic biotech.
Plan grounded in what EntityRisk actually sells
Tied to the PROVEN modules and the people EntityRisk sells to: VPs of HEOR, Market Access, Value and Evidence, Pricing, and Commercial Development across biopharma and select diagnostics.
Days 1 to 30. Absorb and build
- Platform mastery across OutcomesML, ValueML, EvidenceML, PriceML, and CommercialML. Run demos unaided by day 30.
- Study PROVEN Perspectives, Cleo and ARS case studies, the Phelps and Lakdawalla GRACE material.
- Shadow 15 plus live calls. Meet every SME who joins deals.
- Build a 50 to 75 account list with trigger tier scoring.
Days 31 to 60. Activate pipeline
- Target 30 first meetings booked by end of day 60 through outbound.
- Run first unaided discoveries. Pull SMEs with a one page brief every time.
- Work ISPOR or equivalent industry event. Prebook meetings, own the booth.
- Start CFO and VP Finance outreach on top 10 accounts to secure economic buyer access.
Days 61 to 90. Convert and scale
- Advance 2 to 3 opportunities to proposal or paid pilot.
- Close or commit first deal, including expansion on existing logos.
- Publish internal battle cards against Lumanity, Precision AQ, and internal build.
- Deliver 90 day readout with pipeline, themes, and proposed GTM adjustments.
Metrics I would hold myself accountable to
Assuming a standard enterprise SaaS ramp and a quota conversation with the hiring team.
Ramp to full quota production by end of Q2. Deliver 100 percent of annual quota by end of Q4, with stretch of 110 to 120 percent.
At least 4 new logo wins in year one across the mid cap biotech segment. Mix of single module land and multi module land depending on account maturity.
Partner with Dana Panzer and the Client Success team to identify at least 3 expansion plays in existing accounts, whether additional indications, additional geographies, or additional modules.
Publish internal battle cards for the top three competitive scenarios (Lumanity, Precision AQ, internal build) and contribute at least one improvement to the outbound playbook that peer AEs adopt.
Treat ISPOR US, ISPOR Europe, AMCP, JPMorgan, and Biotech Showcase as measurable top of funnel investments. Report specific pipeline attribution from each event.
Ali, thank you again for the time yesterday. This document is meant to share how I think about the AE seat at EntityRisk, not to pitch a finished plan. Plenty of the assumptions will change once I have access to internal data, the real coverage model, and the team. What will not change is the posture: forward looking, numbers driven, and committed to compounding with a team that is already shaping the category.
Happy to go deeper on any section if you have any questions.
Vincent Hembrick